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Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase.

作者信息

van der Wilt C L, van Laar J A, Smid K, Rustum Y M, Peters G J

机构信息

Dept. of Medical Oncology, Free University Hospital, Amsterdam, The Netherlands.

出版信息

Adv Exp Med Biol. 1994;370:109-14. doi: 10.1007/978-1-4615-2584-4_25.

DOI:10.1007/978-1-4615-2584-4_25
PMID:7660870
Abstract
摘要

相似文献

1
Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase.
Adv Exp Med Biol. 1994;370:109-14. doi: 10.1007/978-1-4615-2584-4_25.
2
Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.在小鼠结肠26 - B癌肿瘤模型中，氟嘧啶的治疗效果取决于胸苷酸合成酶抑制的持续时间。
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In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.氟嘧啶对结肠腺癌38的体内抗肿瘤作用及亚叶酸钙的增强作用。
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4
Isolated liver perfusion versus hepatic artery infusion with 5-fluorouracil in a rat model; effects on thymidylate synthase.
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Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.亚叶酸对氟尿嘧啶活性及胸苷酸合成酶表达的影响。
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6
Thymidylate synthetase activity and fluorouracil sensitivity of human colonic cancer and normal mucosal tissue preparations.
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Enzymatic conversion of 5-fluoro-2'-deoxyuridine to 5-fluorouracil or 5-fluoro-2'-deoxyuridine 5'-monophosphate in human tissues.
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8
Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma.
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9
Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.在13个未经筛选的结肠癌细胞系中，胸苷酸合成酶水平作为对5-氟尿嘧啶敏感性的主要预测参数，但对基于叶酸的胸苷酸合成酶抑制剂则不然。
Clin Cancer Res. 1999 Mar;5(3):643-54.
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On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.关于氟嘧啶对免疫缺陷小鼠体内四种人结肠腺癌异种移植瘤的细胞毒性作用机制
Cancer. 1980 Mar 15;45(5 Suppl):1159-67. doi: 10.1002/1097-0142(19800315)45:5+<1159::aid-cncr2820451320>3.0.co;2-z.

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