ZD9331的抗肿瘤活性，一种不可聚谷氨酸化的喹唑啉胸苷酸合成酶抑制剂。 - Suppr

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超能文献

The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor.

作者信息

Jackman A L, Kimbell R, Brown M, Brunton L, Harrap K R, Wardleworth J M, Boyle F T

机构信息

CRC Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, UK.

出版信息

Adv Exp Med Biol. 1994;370:185-8. doi: 10.1007/978-1-4615-2584-4_40.

DOI:10.1007/978-1-4615-2584-4_40

PMID:7660886

Abstract

摘要

相似文献

The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor.ZD9331的抗肿瘤活性，一种不可聚谷氨酸化的喹唑啉胸苷酸合成酶抑制剂。

Adv Exp Med Biol. 1994;370:185-8. doi: 10.1007/978-1-4615-2584-4_40.

Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.新型抗癌药物ZD9331的细胞药理学及体内活性：一种水溶性、不可聚谷氨酸化的基于喹唑啉的胸苷酸合成酶抑制剂

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The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.暴露于两类不同喹唑啉类似物的完整L1210细胞中胸苷酸合成酶的抑制持续时间。

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A potent antitumour quinazoline inhibitor of thymidylate synthetase: synthesis, biological properties and therapeutic results in mice.一种强效的胸苷酸合成酶喹唑啉类抗肿瘤抑制剂：合成、生物学特性及对小鼠的治疗效果

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Molecular characterization of human acute leukemia cell line resistant to ZD9331, a non-polyglutamatable thymidylate synthase inhibitor.对ZD9331耐药的人急性白血病细胞系的分子特征分析，ZD9331是一种不可聚谷氨酸化的胸苷酸合成酶抑制剂。

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Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.喹唑啉胸苷酸合成酶抑制剂ZD1694（拓扑替康）在一种小鼠细胞系和三种人类细胞系中获得性耐药的机制。

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Initiatives with platinum- and quinazoline-based antitumor molecules--Fourteenth Bruce F. Cain Memorial Award Lecture.

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Use of murine L5178Y lymphoma thymidine kinase mutants for in vitro and in vivo antitumour efficacy evaluation of novel thymidylate synthase inhibitors.利用小鼠L5178Y淋巴瘤胸苷激酶突变体进行新型胸苷酸合成酶抑制剂的体外和体内抗肿瘤疗效评估。

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