胆碱能药物对大鼠延迟条件辨别任务的影响。

Cholinergic drug effects on a delayed conditional discrimination task in the rat.

作者信息

Herremans A H, Hijzen T H, Olivier B, Slangen J L

机构信息

Department of Psychopharmacology, Faculty of Pharmacy, Rudolf Magnus Institute of Neuroscience, Utrecht University, The Netherlands.

出版信息

Behav Neurosci. 1995 Jun;109(3):426-35. doi: 10.1037//0735-7044.109.3.426.

DOI:10.1037//0735-7044.109.3.426

PMID:7662153

Abstract

The centrally acting cholinergic antagonist scopolamine (0.025-0.10 mg/kg ip) and the peripherally acting cholinergic antagonist methyl-scopolamine (0.01-0.10 mg/kg) dose dependently impaired discriminability independent of delay in a delayed conditional discrimination task that precludes use of mediating behavior. This indicates that scopolamine does not specifically affect working memory. Drugs that enhance cholinergic transmission neither improved discriminability nor attenuated scopolamine-induced impairments. In a post hoc analysis scopolamine was found to impair discriminability in a delay-dependent manner in rats that performed at a high level in pretest sessions. Methyl-scopolamine impaired performance independently of delay in these rats. The authors suggest that a ceiling effect at short delays produced this Drug x Delay interaction of scopolamine in the best performing rats.

摘要

中枢作用的胆碱能拮抗剂东莨菪碱（腹腔注射0.025 - 0.10毫克/千克）和外周作用的胆碱能拮抗剂甲基东莨菪碱（0.01 - 0.10毫克/千克）在一项延迟条件辨别任务中，剂量依赖性地损害辨别能力，且与延迟无关，该任务排除了中介行为的使用。这表明东莨菪碱不会特异性地影响工作记忆。增强胆碱能传递的药物既不能改善辨别能力，也不能减轻东莨菪碱引起的损害。在事后分析中发现，东莨菪碱在预测试阶段表现高水平的大鼠中以延迟依赖性方式损害辨别能力。甲基东莨菪碱在这些大鼠中独立于延迟损害表现。作者认为，在表现最佳的大鼠中，短延迟时的天花板效应产生了东莨菪碱的这种药物×延迟相互作用。