Spencer D G, Pontecorvo M J, Heise G A
Behav Neurosci. 1985 Dec;99(6):1049-65. doi: 10.1037//0735-7044.99.6.1049.
Rats were trained to stable baselines of lever pressing on a variable intertrial interval continuous nonmatching to sample schedule (CNM) or on an analogous discrimination schedule. Scopolamine reduced accuracy of CNM performance to a similar extent over the three intertrial (retention) intervals: 2.5, 5, and 10 s, results indicating that the drug did not affect the time-dependent process of retention in working memory. When baseline levels of performance accuracy were similar in the CNM and discrimination tasks (but stimulus discriminability was greater in the CNM task), scopolamine reduced accuracy equally in the two procedures. Effects of scopolamine on accuracy of noncorrection trial CNM performance were simulated by reducing stimulus discriminability; however, scopolamine disrupted CNM correction trial performance much more than did reductions in stimulus discriminability. It is concluded that scopolamine's effects on working memory are not limited to possible effects on stimulus discrimination: Scopolamine may also affect retrieval of response rules from reference memory.
大鼠在可变试验间隔连续非匹配样本程序（CNM）或类似的辨别程序上接受训练，以达到稳定的杠杆按压基线。东莨菪碱在三个试验间隔（保留）期（2.5秒、5秒和10秒）内将CNM任务的准确性降低到相似程度，结果表明该药物不影响工作记忆中与时间相关的保留过程。当CNM任务和辨别任务的表现准确性基线水平相似时（但CNM任务中的刺激可辨别性更高），东莨菪碱在两种程序中同等程度地降低了准确性。通过降低刺激可辨别性来模拟东莨菪碱对非校正试验CNM表现准确性的影响；然而，东莨菪碱对CNM校正试验表现的干扰比刺激可辨别性降低的干扰大得多。得出的结论是，东莨菪碱对工作记忆的影响不仅限于对刺激辨别可能产生的影响：东莨菪碱还可能影响从参考记忆中检索反应规则。
