Hentze M W
Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany.
Curr Opin Cell Biol. 1995 Jun;7(3):393-8. doi: 10.1016/0955-0674(95)80095-6.
It has become clear that many vital metabolic circuits and early developmental programs are regulated translationally. Until recently, the mechanisms underlying most of these observations were poorly understood. The past year has witnessed several important advances in the understanding of how the translational apparatus is controlled by different regulatory mechanisms.
很明显,许多重要的代谢途径和早期发育程序是通过翻译进行调控的。直到最近,大多数这些观察结果背后的机制仍知之甚少。过去一年见证了在理解翻译装置如何受到不同调控机制控制方面的几项重要进展。