长QT综合征患者的激发试验与药物反应

Provocative testing and drug response in a patient with the long QT syndrome.

作者信息

Kawade M, Ohe T, Kamiya T

机构信息

Department of Paediatrics, Gifu University School of Medicine, Japan.

出版信息

Br Heart J. 1995 Jul;74(1):67-70. doi: 10.1136/hrt.74.1.67.

DOI:10.1136/hrt.74.1.67

PMID:7662457

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC483949/

Abstract

A girl of 14 with the long QT syndrome (LQTS) and torsades de pointes is reported. Isoprenaline or adrenaline infusions induced torsades de pointes and inversion of the TU wave. Changes in the TU wave during isoprenaline infusion were used to select effective drugs to treat this patient. A beta blocker and calcium channel blocker were selected and the patient had no episodes of syncope for two years. This electrocardiographically guided method may be useful for selecting effective drugs in patients with the LQTS.

摘要

报告了一名14岁患有长QT综合征（LQTS）并发生尖端扭转型室速的女孩。静脉输注异丙肾上腺素或肾上腺素可诱发尖端扭转型室速和TU波倒置。在输注异丙肾上腺素期间观察到的TU波变化被用于选择治疗该患者的有效药物。选用了β受体阻滞剂和钙通道阻滞剂，该患者两年内未发生晕厥发作。这种基于心电图指导的方法可能有助于为LQTS患者选择有效药物。