Char D H, Miller T
Department of Ophthalmology, University of California, San Francisco 94143-0730, USA.
Br J Ophthalmol. 1995 Jul;79(7):692-6. doi: 10.1136/bjo.79.7.692.
AIMS/BACKGROUND: This study was performed to ascertain the diagnostic accuracy rate of non-invasive tests in patients with presumed uveal melanomas scheduled to be treated with either irradiation or cyclochoroidectomy.
One hundred consecutive patients who had non-invasive tests followed by fine needle aspiration biopsy (FNAB) as prior alternative treatment were analysed retrospectively.
In 86 cases the diagnosis of uveal melanoma was confirmed on FNAB. In five cases false negative results were obtained. In nine patients a diagnosis other than a uveal melanoma was made on the basis of cytopathology. No significant morbidity and no evidence of tumour spread occurred.
In presumed uveal melanomas eligible for treatment with alternative therapies, the diagnostic accuracy of non-invasive tests is not as good as with larger tumours that require enucleation. Fine needle aspiration biopsy data resulted in correct management of 9% of cases that were thought to have uveal melanomas on non-invasive tests, but had other lesions on cytopathological evaluation.
目的/背景：本研究旨在确定计划接受放疗或睫状体脉络膜切除术治疗的疑似葡萄膜黑色素瘤患者中，非侵入性检查的诊断准确率。
回顾性分析连续100例接受非侵入性检查后进行细针穿刺活检（FNAB）作为先前替代治疗的患者。
86例患者经FNAB确诊为葡萄膜黑色素瘤。5例结果为假阴性。9例患者根据细胞病理学诊断为非葡萄膜黑色素瘤。未发生明显的并发症，也没有肿瘤扩散的证据。
对于适合采用替代疗法治疗的疑似葡萄膜黑色素瘤，非侵入性检查的诊断准确性不如对需要眼球摘除术的较大肿瘤的诊断准确性。细针穿刺活检数据使9%的病例得到了正确处理，这些病例在非侵入性检查中被认为患有葡萄膜黑色素瘤，但在细胞病理学评估中发现有其他病变。
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