Ar'Rajab A, Snoj M, Larsson K, Bengmark S
Department of Surgery, Lund University Hospital, Sweden.
Eur J Surg. 1995 May;161(5):341-4.
To find out if the previously described ability of phosphatidylcholine to reduce peritoneal adhesions is specific to it, or if other phospholipids such as phosphatidylinositol (PI) or DL-phosphatidylcholine dilauryl (DL-PC) have similar effects.
Laboratory experiment.
University hospital, Sweden.
160 rats which had had intraperitoneal adhesions induced at laparotomy by peritoneal defects repaired in one of two models.
PI was given intraperitoneally either once in a dose of 20 or 40 mg/rat at the end of the operation, or at the end of the operation and repeated on the second and third postoperative days. DL-PC was given once at the end of the operation in a dose of either 20 or 40 mg/rat.
Adhesions were assessed a week after operation by an observer who was unaware of the treatment given.
PI given on three consecutive days significantly reduced adhesions formed postoperatively in both models (p < 0.05). Neither PI nor DL-PC given in a single dose of 20 mg/rat had any effect, whereas both PI and DL-PC given in single doses of 40 mg/rat significantly reduced adhesions (p < 0.05).
Both PI and DL-PC are effective in the prevention and limiting of postoperative adhesions in rats.
探究此前所描述的磷脂酰胆碱减少腹膜粘连的能力是否为其特有，或者其他磷脂如磷脂酰肌醇（PI）或二月桂酰磷脂酰胆碱（DL-PC）是否有类似作用。
实验室实验。
瑞典大学医院。
160只大鼠，通过两种模型之一修复腹膜缺损，在剖腹手术时诱导产生腹膜粘连。
在手术结束时，以20或40毫克/大鼠的剂量给大鼠腹腔注射PI一次，或者在手术结束时注射，并在术后第二天和第三天重复注射。在手术结束时，以20或40毫克/大鼠的剂量给大鼠一次性注射DL-PC。
术后一周由不知道所给予治疗的观察者评估粘连情况。
连续三天给予PI可显著减少两种模型术后形成的粘连（p<0.05）。以20毫克/大鼠的单剂量给予PI或DL-PC均无任何效果，而以40毫克/大鼠的单剂量给予PI和DL-PC均显著减少了粘连（p<0.05）。
PI和DL-PC在预防和限制大鼠术后粘连方面均有效。
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