Albújar P, Díaz J, Tantaleán E, Salinas E, Urtecho F
Servicio de Anatomo-Patología, Hospital Belén, Trujillo, Perú.
Rev Gastroenterol Peru. 1995 May-Aug;15(2):141-51.
This retrospective study evaluated 32 patients with primary gastrointestinal lymphoma managed at Belen Hospital, Trujillo, Peru, from 1966 to 1994 to determine their clinicopathologic findings and identify those prognostic factors that influenced in the 5-year survival. Median age was 44.2 years. The male to female ratio was 1.3:1 and seventh decade was the most involved. Abdominal pain, the predominant symptom, was present in gastric (100%) and intestinal (91%) lymphoma. Small intestine was involved in 62.5% cases, followed by stomach (28.1%). Most common stage was II1E (50%) and predominant histological was high grade-MALT type lymphoma (81.3%). Five year survival rate was 29% for those who received some kind of treatment (n = 30): It was 38% for whom underwent surgery plus chemotherapy and/or radiotherapy compared to those who only underwent surgery (23%) (p < 0.05). Factors as histological type (p < 0.005), stage (p < 0.005) and tumoral size (p < 0.05) were associated with long term survival. We conclude that early diagnosis is important to define management in these patients and post-operatory adjuvant treatment should be considered to obtain a longer survival.
这项回顾性研究评估了1966年至1994年在秘鲁特鲁希略贝伦医院接受治疗的32例原发性胃肠道淋巴瘤患者,以确定其临床病理特征,并找出影响5年生存率的预后因素。中位年龄为44.2岁。男女比例为1.3:1,最常见于第七个十年。腹痛是主要症状,在胃淋巴瘤(100%)和肠淋巴瘤(91%)中均有出现。62.5%的病例累及小肠,其次是胃(28.1%)。最常见的分期是II1E期(50%),主要组织学类型是高级别MALT型淋巴瘤(81.3%)。接受某种治疗的患者(n = 30)的5年生存率为29%:接受手术加化疗和/或放疗的患者为38%,而仅接受手术的患者为23%(p < 0.05)。组织学类型(p < 0.005)、分期(p < 0.005)和肿瘤大小(p < 0.05)等因素与长期生存相关。我们得出结论,早期诊断对于确定这些患者的治疗方案很重要,应考虑术后辅助治疗以获得更长的生存期。