Popova E D, Puzin M N, Kolyvanov G B, Litvin A A
Eksp Klin Farmakol. 1995 May-Jun;58(3):53-4.
The pharmacokinetics of baclofen was studied in the rat blood plasma and brain. The concentrations of the agent were found to be considerably lower in the brain than in the plasma. This is associated with the weakly pronounced lipophilicity of the agent in question and with the protective properties of the blood-brain barrier. Baclofen penetrates into the brain middle regions to a greater extent than into cerebral hemispheres.
在大鼠血浆和脑中研究了巴氯芬的药代动力学。发现该药物在脑中的浓度明显低于血浆中的浓度。这与该药物较弱的亲脂性以及血脑屏障的保护特性有关。巴氯芬进入脑中部区域的程度比进入大脑半球的程度更大。
