Khokhlova L I, Zav'ialov A V
Eksp Klin Farmakol. 1995 May-Jun;58(3):57-9.
Morphine was studied for its effects on the baseline alcohol motivation in experiments on ethanol-preferring (EPRs) and -rejecting (ERRs) rats. The intraperitoneal administration of morphine in doses of 0.05 and 1 mg/kg caused an increase in ethanol uptake in EPRs both during administration of morphine and after its discontinuation and did not affect the voluntary consumption of morphine solution. The above doses induced no increases in ethanol uptake in ERRs as compared with the controls and stimulated their voluntary consumption of morphine solution. It is concluded that in EPRs, alcohol motivation is enhanced by morphine and the latter used in a dose of 0.05 mg/kg may cause the withdrawal syndrome in ERRs.
在对嗜乙醇（EPRs）和拒乙醇（ERRs）大鼠进行的实验中，研究了吗啡对基线酒精动机的影响。腹腔注射0.05和1mg/kg剂量的吗啡，导致EPRs在吗啡给药期间及其停药后乙醇摄取增加，且不影响吗啡溶液的自愿消耗量。与对照组相比，上述剂量未引起ERRs乙醇摄取增加，但刺激了它们对吗啡溶液的自愿消耗量。得出的结论是，在EPRs中，吗啡增强了酒精动机，而0.05mg/kg剂量的吗啡可能会导致ERRs出现戒断综合征。
