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[局部皮质类固醇疗法对实验性炎症性病变中眼内压及眼内水动力学和血液动力学的影响]

[The effect of local corticosteroid therapy on ophthalmic tonus and ocular hydro- and hemodynamics in experimental inflammatory pathology].

作者信息

Chaĭka L A, Povolotskaia V A

出版信息

Eksp Klin Farmakol. 1995 May-Jun;58(3):62-4.

PMID:7663304
Abstract

The laboratory samples of 0.1% dexamethasone and 1% hydrocortisone eye drops which had been designed at the State Research Center of Drugs were investigated for their effects on intraocular pressure in the presence of photokeratitis caused by UV irradiation. Producing pronounced antiinflammatory effects, the daily triple instillations of corticosteroids for 9 days tended to gradually increase the ophthalmotone induced both by the imbalance of production and outflow of intraocular fluid and by ocular hemodynamic disorders associated with the enhanced blood filling of the choroidal vessels and with the higher intensity of pulse oscillations.

摘要

对国家药物研究中心设计的0.1%地塞米松和1%氢化可的松眼药水的实验室样本进行了研究,观察它们在紫外线照射引起的光角膜炎情况下对眼压的影响。皮质类固醇每日三次滴注,持续9天,产生明显的抗炎作用,这往往会使因眼内液生成与流出失衡以及与脉络膜血管充血增强和脉搏振荡强度较高相关的眼血流动力学紊乱所引起的眼压逐渐升高。

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