Blauer G, Akkawi M
Department of Biological Chemistry, Hebrew University, Jerusalem, Israel.
Biochem Mol Biol Int. 1995 Feb;35(2):231-5.
Very rapid production in vitro of a particular type of hematin (B-hematin) with high yield at physiological pH and temperature is presently reported, using a simple chemical system including an organic acid in the absence of any enzyme. B-hematin is characterized by infrared spectra and solubility properties. The antimalarial drug chloroquine practically prevents formation of this hematin under the conditions used. It has recently been suggested that the purified malaria pigment hemozoin is identical with beta-hematin, a form of ferriprotoporphyrin IX sparingly soluble in different solvents which is prepared under non-physiological conditions. Relations between B- and beta-hematin and possible mechanisms of hemozoin formation and antimalarial drug action, are discussed.
目前报道了在生理pH值和温度下，使用一种简单的化学体系（包括一种有机酸且无任何酶）能在体外非常快速地高产特定类型的血红素（β-血红素）。β-血红素通过红外光谱和溶解性进行表征。抗疟药物氯喹在所用条件下实际上可阻止这种血红素的形成。最近有人提出，纯化的疟色素疟原虫血色素与β-血红素相同，β-血红素是一种在非生理条件下制备的、在不同溶剂中微溶的高铁原卟啉IX形式。讨论了β-血红素和β-血红素之间的关系以及疟原虫血色素形成和抗疟药物作用的可能机制。
