亚硝酸盐与次氯酸反应生成硝化物质。

The production of nitrating species by the reaction between nitrite and hypochlorous acid.

作者信息

Kono Y

机构信息

Department of Bacteriology, Faculty of Medicine, Tottori University, Japan.

出版信息

Biochem Mol Biol Int. 1995 Jun;36(2):275-83.

PMID:7663431

Abstract

Nitrite inhibited the killing of Escherichia coli by hypochlorous acid. The protection curve was sigmoid. Complete protection occurred at nitrite concentrations greater than that of hypochlorous acid. Hypochlorous acid reacts rapidly with nitrite, as shown by phenolic nitration, using 4-hydroxyphenylacetic acid. The nitration was biphasic. Amines and amino acids inhibited the nitration, but metal chelators and hydroxyl radical scavengers except for dimethylsulfoxide did not. The reaction between hypochlorous acid and nitrite yields nitrating species such as nitrogen dioxide or nitronium ion. Nitrite could protect E. coli by removing toxic nitrating species by hypochlorous acid.

摘要

亚硝酸盐抑制了次氯酸对大肠杆菌的杀伤作用。保护曲线呈S形。当亚硝酸盐浓度高于次氯酸浓度时，会出现完全保护作用。如使用4-羟基苯乙酸进行酚类硝化反应所示，次氯酸与亚硝酸盐反应迅速。硝化反应是双相的。胺类和氨基酸会抑制硝化反应，但除二甲基亚砜外的金属螯合剂和羟基自由基清除剂不会。次氯酸与亚硝酸盐之间的反应会产生诸如二氧化氮或硝鎓离子等硝化物种。亚硝酸盐可以通过去除次氯酸产生的有毒硝化物种来保护大肠杆菌。