Evans D A, Krahn P, Narayanan N
Riyadh Armed Forces Hospital, Kingdom of Saudi Arabia.
Pharmacogenetics. 1995 Apr;5(2):64-71. doi: 10.1097/00008571-199504000-00002.
Hitherto no estimate has been available of the genetic polymorphisms of S-mephenytoin hydroxylation in the Saudi Arabian or any other Middle Eastern population. A total of 102 healthy Saudi Arabian volunteer subjects were tested simultaneously with mephenytoin and dextromethorphan. Two poor metabolizers of S-mephenytoin and two poor metabolizers of dextromethorphan were found. Also 55 healthy Filipino volunteer subjects were tested and 13 found to be poor metabolizers of S-mephenytoin, whilst none were found to be poor metabolizers of dextromethorphan. The Saudi Arabian population thus appears to resemble Europeans in the frequency of poor metabolizers of S-mephenytoin, but resembles Orientals in the frequency of poor metabolizers of dextromethorphan. The Filipino sample as expected resembles other Oriental samples in the frequencies of poor metabolizers of both drugs.
迄今为止，尚未有关于沙特阿拉伯或任何其他中东人群中S-美芬妥因羟化遗传多态性的评估。共有102名健康的沙特阿拉伯志愿者受试者同时接受了美芬妥因和右美沙芬的测试。发现了两名S-美芬妥因慢代谢者和两名右美沙芬慢代谢者。此外，对55名健康的菲律宾志愿者受试者进行了测试，发现13名是S-美芬妥因慢代谢者，而未发现右美沙芬慢代谢者。因此，沙特阿拉伯人群在S-美芬妥因慢代谢者的频率上似乎与欧洲人相似，但在右美沙芬慢代谢者的频率上与东方人相似。正如预期的那样，菲律宾样本在两种药物慢代谢者的频率上与其他东方样本相似。
