阿曼人群中芳胺N - 乙酰基转移酶2（nat2）基因型的分布。
Distribution of arylamine N-acetyltransferase 2 (nat2) genotypes among Omanis.
作者信息
Tanira Musbah O M, Simsek Mehmet, Al Balushi Khalid, Al Lawatia Khulood, Al Barawani Hameedah, Bayoumi Riad A
机构信息
Departments of Pharmacology and.
出版信息
J Sci Res Med Sci. 2003 Aug;5(1-2):9-14.
Abstract
OBJECTIVE
to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis.
METHOD
Identify the most common known polymorphisms of NAT*2 gene namely, G(191)A, C(282)T, C(341)T, C(481)T, G(590)A, A(803)G and G(857)A using PCR-RFLP analysis.
RESULTS
Eleven allele variants (3 alternative) and 30 different genotypes were determined. The commonest alleles were found to be NAT5B, NAT26A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25.
CONCLUSION
A new allele variant containing G(590)A, C(282)T and T(341)C polymorphisms was found in one subject (was named NAT2*5J). The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively.
摘要
目的
确定127名无亲缘关系的表面健康的阿曼人的芳胺N - 乙酰转移酶（NAT2）基因型。
方法
使用聚合酶链反应-限制性片段长度多态性分析（PCR-RFLP分析）鉴定NAT*2基因最常见的已知多态性，即G(191)A、C(282)T、C(341)T、C(481)T、G(590)A、A(803)G和G(857)A。
结果
确定了11个等位基因变体（3个替代型）和30种不同基因型。发现最常见的等位基因是NAT5B、NAT26A和NAT*4，其相应频率分别为0.362、0.248和0.189。快速乙酰化酶等位基因的总体频率为0.25。
结论
在一名受试者中发现了一种新的包含G(590)A、C(282)T和T(341)C多态性的等位基因变体（命名为NAT2*5J）。发现最常见的基因型是5B/5B、5B/6A、4/5B、4/6A，频率分别为0.165、0.157、0.118、0.110和0.079。
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