Pini L A, Sandrini M, Vitale G
Clinical Pharmacology Unit, University of Modena, Italy.
Inflamm Res. 1995 Jan;44(1):30-5. doi: 10.1007/BF01630485.
The pain-threshold in the hot-plate test and serotonin (5-HT) receptor binding capacity in the cortex and pontine areas of rat brain were studied after intraperitoneal (ip) administration of acetyl salicylate of lysine equivalent to 400 mg/kg of acetylsalicylic acid (ASA). The antinociceptive activity of ASA was prevented by ip pre-treatment with Parachlorophenylalanine (PCPA) at the rate of 100 mg/kg/day for 4 days. PCPA pre-treatment increased the number of 5-HT receptors and abolished the ASA-induced reduction in 5-HT receptor binding capacity in the cortex but did not affect serum salicylate levels. These results provide support for the hypothesis that the antinociceptive action of ASA, at least in the hot-plate test, involves the central serotonergic system.
腹腔注射相当于400mg/kg乙酰水杨酸（ASA）的赖氨酸乙酰水杨酸后，研究了大鼠脑皮层和脑桥区域在热板试验中的痛阈以及5-羟色胺（5-HT）受体结合能力。以100mg/kg/天的剂量腹腔注射对氯苯丙氨酸（PCPA）预处理4天，可阻断ASA的抗伤害感受活性。PCPA预处理增加了5-HT受体的数量，消除了ASA诱导的皮层5-HT受体结合能力的降低，但不影响血清水杨酸水平。这些结果支持了以下假说：至少在热板试验中，ASA的抗伤害感受作用涉及中枢5-羟色胺能系统。
