Pini L A, Vitale G, Sandrini M
Department of Internal Medicine, University of Modena, Italy.
Pharmacology. 1997 Feb;54(2):84-91. doi: 10.1159/000139473.
Acetylsalicylic acid (ASA), 400 mg/kg i.p., displayed antinociceptive activity in both the hot-plate and the formalin test. ASA significantly increased brain serotonin (5-HT) content and reduced the number of 5-HT2 receptors in cortical brain membranes 30 min after drug administration. Pretreatment with naloxone abolished the antinociceptive activity of both ASA and morphine in the hot-plate and formalin tests and prevented the increase in cerebral 5-HT concentration and the reduction in 5-HT2 receptors in cortical membranes induced by ASA. The serum salicylate concentrations were not affected by pretreatment with naloxone. These data indicate a central antinociceptive activity of ASA and suggest that ASA may exert its antinociceptive action through serotonergic and opiatergic pathways.
腹腔注射400毫克/千克的乙酰水杨酸（ASA）在热板法和福尔马林试验中均显示出抗伤害感受活性。给药30分钟后，ASA显著增加了脑血清素（5-HT）含量，并减少了大脑皮层细胞膜中5-HT2受体的数量。在热板法和福尔马林试验中，用纳洛酮预处理可消除ASA和吗啡的抗伤害感受活性，并阻止ASA诱导的脑5-HT浓度升高和大脑皮层细胞膜中5-HT2受体数量减少。血清水杨酸盐浓度不受纳洛酮预处理的影响。这些数据表明ASA具有中枢抗伤害感受活性，并提示ASA可能通过5-羟色胺能和阿片能途径发挥其抗伤害感受作用。
