Kurz A, Egensperger R, Lautenschlager N, Haupt M, Altland K, Graeber M B, Müller U
Psychiatrische Klinik, Technischen Universität, München.
Z Gerontol Geriatr. 1995 May-Jun;28(3):195-9.
The relevance of the apolipoprotein E epsilon 4 allele as risk factor for Alzheimer's disease is independent of age. This was demonstrated in 126 patients and 72 healthy controls. The age in both groups varied between 44 and 95 years. An earlier onset of symptoms among carriers of the epsilon 4 allele, however, was observed only in the oldest patients. This may reflect a selection bias which is due to the association of the epsilon 4 allele with two competitive age-dependent risks: for Alzheimer's disease and for coronary heart disease. In a subsample of 64 patients who had participated in a longitudinal study no relationship was found between the apolipoprotein E genotype and clinical symptoms or symptom progression.
载脂蛋白E ε4等位基因作为阿尔茨海默病风险因素的相关性与年龄无关。这在126例患者和72例健康对照中得到了证实。两组的年龄在44岁至95岁之间。然而，仅在年龄最大的患者中观察到ε4等位基因携带者症状出现较早。这可能反映了一种选择偏倚，这是由于ε4等位基因与两种相互竞争的年龄依赖性风险相关：阿尔茨海默病和冠心病。在参与纵向研究的64例患者的子样本中，未发现载脂蛋白E基因型与临床症状或症状进展之间存在关联。
