Dagianti A, Agati L, Rosanio S, Dagianti A, Penco M, Tocchi M, Fedele F
Dipartimento di Scienze Cardiovascolari e Respiratorie, Università degli Studi La Sapienza, Roma.
Cardiologia. 1995 Mar;40(3):157-65.
The present study, selecting 39 patients undergoing elective coronary angioplasty (PTCA) with signs of myocardial ischemia during supine bicycle exercise stress test (EST) before PTCA and on medical therapy, was designed: to evaluate the efficacy of angiographically successful PTCA on functional capacity, in terms of work load, time of exercise and rate-pressure product (RPP), by comparing pre- and post-PTCA-EST performed in patients with post-PTCA disappearance (Group I, 44%) or persistence (Group II, 56%) of myocardial ischemia, and in the latter, to evaluate the effects of medical therapy, by repeating EST after its addition; to investigate the influence of PTCA on regional function, assessed by a 11 segment model and graded as usual, in the 25 patients group with pre-PTCA exercise-induced wall motion abnormalities, disappearing (Group A, 64%) or persisting (Group B, 36%) after the interventional procedure; to examine by a 12-month follow-up the eventuality of recurrent anginal symptoms, in the presence of myocardial ischemic signs in the territory supplied by the dilated vessel and/or of angiographic restenosis, in relation to the result of post-PTCA-EST. The results of our study showed a significant improvement in functional capacity after PTCA only in Group I patients, whereas in Group II patients effort tolerance significantly increased only after medical therapy, which was associated with the disappearance of myocardial ischemia. With regard to follow-up, exercise echocardiography showed a positive and negative predictive value for angina recurrence with angiographic restenosis of 78 and 92%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究选取了39例在择期冠状动脉血管成形术(PTCA)前进行仰卧踏车运动负荷试验(EST)时有心肌缺血征象且接受药物治疗的患者,旨在:通过比较PTCA术后心肌缺血消失(I组,44%)或持续存在(II组,56%)的患者PTCA前后的EST,评估血管造影成功的PTCA对功能能力(以工作量、运动时间和心率-血压乘积(RPP)衡量)的疗效,对于II组患者,在加用药物治疗后重复EST,以评估药物治疗的效果;在25例PTCA术前运动诱发室壁运动异常的患者中,研究PTCA对局部功能的影响,通过11节段模型评估并按常规分级,干预术后室壁运动异常消失(A组,64%)或持续存在(B组,36%);通过12个月的随访,检查在扩张血管供血区域存在心肌缺血征象和/或血管造影再狭窄的情况下,与PTCA术后EST结果相关的复发性心绞痛症状的可能性。我们的研究结果显示,仅I组患者PTCA后功能能力有显著改善,而II组患者仅在药物治疗后运动耐力显著增加,且这与心肌缺血的消失相关。关于随访,运动超声心动图显示,对于伴有血管造影再狭窄的心绞痛复发,其阳性和阴性预测值分别为78%和92%。(摘要截断于250字)