Wegner H, Dadaliaris D, Engelmann L, Graf B, Schneider D
Z Gesamte Inn Med. 1975 Sep 15;30(18):186-9.
In numerous controlled studies the effectivity of the streptokinase therapy of the acute myocardial infarction is proved by a significant decrease of the early lethality. The main difference of the therapeutic methods lies in the duration of the application of streptokinase. Of the number of patients of an intensive therapy ward for internal diseases comparisons of the results of therapy of one year with short-term lysis (3 hours) are contrasted with one year with protracted lysis therapy (24-72 hours). The findings demonstrated plead for the fact that by means of the short-time lysis may also be achieved good, perhaps even better results. Issuing from the therapeutic mechanisms of the lysis therapy in the sense of a prevention of the formation of thrombi in disturbed microcirculation by the achieved hyperplasminaemia the short-term lysis is to be regarded as optimum introduction of an anticoagulant long-term therapy.
在众多对照研究中，链激酶治疗急性心肌梗死的有效性通过早期死亡率的显著降低得到证实。治疗方法的主要差异在于链激酶的应用时长。在内科重症监护病房的患者中，将短期溶栓（3小时）治疗一年的结果与长期溶栓治疗（24 - 72小时）一年的结果进行了比较。研究结果表明，通过短期溶栓也可能取得良好的，甚至可能更好的效果。从溶栓治疗的机制来看，即通过所达到的高纤溶血症预防微循环紊乱中血栓的形成，短期溶栓应被视为抗凝长期治疗的最佳引入方式。
