Hart R W, Keenan K, Turturro A, Abdo K M, Leakey J, Lyn-Cook B
National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.
Fundam Appl Toxicol. 1995 May;25(2):184-95. doi: 10.1006/faat.1995.1054.
The modulatory effects of caloric intake on the rate and extent of both spontaneous and induced disease incidence is well known, but the significance of these effects in the interpretation of testing data has only recently become appreciated. This is especially true relative to the impact of caloric intake on both survival and background incidence for common tumors. In order to enhance the health and survival of animals ongoing chronic toxicity testing it has been suggested that such tests should restrict food consumption. Although this restriction will result in increasing survival of the test animals, it may also effect the expression of toxicity by altering agent metabolism and disease progression. Focus in this symposium is on the necessity to control dietary consumption in toxicity tests (dietary control), and if such a need does exist to what level of consumption should be diet be focused (caloric restriction).
热量摄入对自发和诱发疾病发生率的速率及程度的调节作用是众所周知的，但这些作用在测试数据解释中的重要性直到最近才得到重视。这在热量摄入对常见肿瘤的存活率和背景发生率的影响方面尤为如此。为了提高进行慢性毒性试验的动物的健康水平和存活率，有人建议此类试验应限制食物消耗。尽管这种限制会提高试验动物的存活率，但它也可能通过改变药物代谢和疾病进展来影响毒性的表达。本次研讨会的重点是在毒性试验中控制饮食消耗（饮食控制）的必要性，如果确实有这种需求，饮食应控制在何种消耗水平（热量限制）。
