Kapfhamer D, Miller D E, Lambert S, Bennett V, Glover T W, Burmeister M
Department of Human Genetics, University of Michigan, Ann Arbor, USA.
Genomics. 1995 May 1;27(1):189-91. doi: 10.1006/geno.1995.1023.
The ankyrin3 gene encodes a novel form of ankyrin, AnkyrinG, expressed in multiple tissues but characteristically present at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. We have localized ANK3 to human Chromosome 10q21 by fluorescence in situ hybridization. The position of the murine homologue was determined by intersubspecific backcross analysis, mapping Ank3 to mouse Chromosome 10, between microsatellite marker D10Mit31 and the Bcr gene. This interval is known to comprise a region syntenic to human 10q. The localization of ANK3 is a preliminary step in identifying neurological disorders potentially associated with the gene.
锚蛋白3基因编码一种新型的锚蛋白，即锚蛋白G，它在多种组织中表达，但特征性地存在于中枢和外周神经系统神经元的轴突起始段和郎飞结处。我们通过荧光原位杂交将ANK3定位于人类染色体10q21。通过种间回交分析确定了小鼠同源物的位置，将Ank3定位于小鼠染色体10上，位于微卫星标记D10Mit31和Bcr基因之间。已知该区间包含与人类10q同线的区域。ANK3的定位是鉴定可能与该基因相关的神经系统疾病的初步步骤。
