Yang S, Soubrane O, Cailmail S, Gaudin C, Moreau R, Belghiti J, Lebrec D
Laboratoire d'Hémodynamique Splanchnique, Unité de REcherches de Physiopathologie Hépatique (INSERM U-24), Hôpital Beaujon, Clichy, France.
J Hepatol. 1995 Apr;22(4):481-5. doi: 10.1016/0168-8278(95)80113-8.
BACKGROUND/AIMS: Since portal tributary blood flow is increased in portal hypertension due to cirrhosis, a reduction in mesenteric arterial blood flow should decrease portal pressure.
Calibrated stenosis of the superior mesenteric artery was performed in bile duct ligated rats, using a 22-gauge needle. Arterial stenosis was performed 4 weeks after bile duct ligation. Hemodynamic studies were performed in the 5th week following bile duct ligation in conscious rats.
At that time, no digestive tract alterations were observed. In rats with mesenteric arterial stenosis, portal pressure was 12.2 +/- 2.0 mmHg; this value was lower than in rats with cirrhosis without arterial stenosis (14.5 +/- 1.1 mmHg) but higher than normal rats (5.8 +/- 0.7 mmHg). In rats with cirrhosis with mesenteric arterial stenosis, portal tributary and mesenteric blood flows were lower than in rats with cirrhosis without arterial stenosis and not significantly different from normal rats. In rats with mesenteric stenosis, cardiac index was significantly lower than in rats with cirrhosis and not significantly different from normal rats.
This study shows that calibrated superior mesenteric arterial stenosis normalized portal tributary blood flow and reduced but did not normalize the degree of portal hypertension.
背景/目的：由于肝硬化导致门静脉高压时门静脉分支血流增加，肠系膜动脉血流减少应可降低门静脉压力。
使用22号针在胆管结扎大鼠中对肠系膜上动脉进行校准狭窄。在胆管结扎4周后进行动脉狭窄。在胆管结扎后第5周对清醒大鼠进行血流动力学研究。
此时，未观察到消化道改变。在肠系膜动脉狭窄的大鼠中，门静脉压力为12.2±2.0 mmHg；该值低于无动脉狭窄的肝硬化大鼠（14.5±1.1 mmHg），但高于正常大鼠（5.8±0.7 mmHg）。在伴有肠系膜动脉狭窄的肝硬化大鼠中，门静脉分支和肠系膜血流低于无动脉狭窄的肝硬化大鼠，与正常大鼠无显著差异。在肠系膜狭窄的大鼠中，心脏指数显著低于肝硬化大鼠，与正常大鼠无显著差异。
本研究表明，校准的肠系膜上动脉狭窄可使门静脉分支血流正常化，并降低但未使门静脉高压程度正常化。
