McGuire M K, Littleton A W, Schulze K J, Rasmussen K M
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.
J Nutr. 1995 Sep;125(9):2400-6. doi: 10.1093/jn/125.9.2400.
This study was designed to determine if nutrient availability during gestation and early life modifies the effects of subsequent dietary intake on reproductive and lactation performance. Rat pups, whose mothers had been allowed free access to food or were food-restricted to 50% of ad libitum consumption were assigned to free access or food restricted groups after weaning, creating 4 groups (pre- and postweaning diet). Pre- and postweaning diets interacted significantly to influence age at conception, number of pups born, and milk yield on d 14 of lactation. Early undernutrition deterred conception in dams later allowed free access to food and resulted in fewer pups born to dams later allowed free access to food, but not those in the food-restricted group. By d 15 of lactation, only dietary treatment after weaning influenced litter weight. Milk yield per gram dam weight was not impaired in the food restricted-ad libitum group but was lowered in dams in the ad libitum-food restricted group. Milk yield per gram litter weight was not impaired in ad libitum-food restricted dams but was reduced in food restricted-ad libitum dams. These results extend to the preweaning period our previous finding that past or current food restriction impairs reproductive success and decreases milk yield in rats.
本研究旨在确定妊娠期和生命早期的营养可利用性是否会改变后续饮食摄入对生殖和泌乳性能的影响。将其母亲可自由获取食物或食物摄入量限制为随意摄入量50%的幼鼠在断奶后分为自由采食组或限食组，从而形成4组（断奶前和断奶后饮食）。断奶前和断奶后饮食存在显著交互作用，影响受孕年龄、产仔数以及泌乳第14天的产奶量。早期营养不足阻碍了后期可自由获取食物的母鼠受孕，导致后期可自由获取食物的母鼠产仔数减少，但食物限制组的母鼠未出现这种情况。到泌乳第15天，只有断奶后的饮食处理会影响窝重。限食-自由采食组每克母鼠体重的产奶量未受影响，但自由采食-限食组的母鼠产奶量降低。自由采食-限食组母鼠每克窝重的产奶量未受影响，但限食-自由采食组母鼠的产奶量降低。这些结果将我们之前的发现扩展到断奶前期，即过去或当前的食物限制会损害大鼠的繁殖成功率并降低产奶量。
