Shimizu M
Second Department of Internal Medicine, Yokohama City University School of Medicine.
J Cardiol. 1995 Jul;26(1):15-21.
The correlation between the time-course changes in the serum concentration of myosin light chain 1 (ML-1) and left ventricular (LV) function was investigated in 37 patients with initial anterior acute myocardial infarction (AMI) after successful reperfusion. All patients were confirmed to have coronary arteries recanalized to TIMI grade 3 within 6 hours of AMI and patent arteries about 2 weeks after recanalization. LV function was assessed by left ventriculography. The patients were divided into two groups according to the time-course changes in the serum concentration of ML-1; 20 who showed an early peak of the serum ML-1 level within 24 hours and a late peak 3 to 5 days after recanalization (bimodal pattern: group B), and 17 who showed a single peak of the serum ML-1 level after recanalization (unimodal pattern: group U). The sum of ST elevation in an electrocardiogram before reperfusion and the additional ST elevation during reperfusion were both greater in group B than in group U (p < 0.1 and p < 0.05, respectively). The peak serum concentration of creatine kinase was significantly greater in group B than group U. LV dilatation was more extensive and the improvement of LV function was poorer in group B compared to group U.(ABSTRACT TRUNCATED AT 250 WORDS)
在37例初次发生前壁急性心肌梗死（AMI）且再灌注成功的患者中，研究了肌球蛋白轻链1（ML-1）血清浓度的时间进程变化与左心室（LV）功能之间的相关性。所有患者均在AMI后6小时内冠状动脉再通至TIMI 3级，且再通后约2周血管通畅。通过左心室造影评估LV功能。根据ML-1血清浓度的时间进程变化将患者分为两组：20例在24小时内出现血清ML-1水平早期峰值且再通后3至5天出现晚期峰值（双峰模式：B组），17例在再通后出现血清ML-1水平单峰（单峰模式：U组）。再灌注前心电图ST段抬高总和以及再灌注期间额外的ST段抬高在B组均高于U组（分别为p < 0.1和p < 0.05）。B组肌酸激酶的血清峰值浓度显著高于U组。与U组相比，B组LV扩张更广泛，LV功能改善更差。（摘要截短至250字）
