Odashima K
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Yakugaku Zasshi. 1995 Jun;115(6):431-45. doi: 10.1248/yakushi1947.115.6_431.
Studies on host-guest molecular recognition at membrane surfaces, which involves changes in the membrane potential, are described. A special focus was placed on basic approaches for the potentiometric discrimination of organic guests in liquid membrane systems. The following modes of host-guest interaction have been exploited for the structure discrimination based on membrane potential changes. (i) Electrostatic interaction by protonated polyamine hosts to discriminate organic anion guests. (ii) Complementary base pairing by hosts having a cytosine residue to discriminate nucleotide guests bearing guanine and adenine bases. (iii) Inclusion of nonpolar moieties of guests by a calix[6]arene hexaester or a beta-cyclodextrin derivative to discriminate amine guests having different steric structures. Some characteristic aspects of host-guest molecular recognition at membrane surfaces are discussed in comparison with those in homogeneous solutions.
本文描述了关于膜表面主客体分子识别的研究，该过程涉及膜电位的变化。特别关注了液膜体系中对有机客体进行电位测定鉴别时的基本方法。基于膜电位变化，以下主客体相互作用模式已被用于结构鉴别：（i）质子化多胺主体通过静电相互作用鉴别有机阴离子客体；（ii）含有胞嘧啶残基的主体通过互补碱基配对鉴别带有鸟嘌呤和腺嘌呤碱基的核苷酸客体；（iii）杯[6]芳烃六酯或β-环糊精衍生物包合客体的非极性部分以鉴别具有不同空间结构的胺类客体。与均相溶液中的情况相比，还讨论了膜表面主客体分子识别的一些特征。
