雄性小鼠交配后γ-氨基丁酸-苯二氮䓬受体复合物及外周苯二氮䓬受体的变化。

Changes in GABA-benzodiazepine receptor complex and in peripheral benzodiazepine receptors in male mice after copulation.

作者信息

Saano V, Rägo L, Tupala E, Airaksinen M M

机构信息

Department of Pharmacology and Toxicology, University of Kuopio, Finland.

出版信息

Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):529-33. doi: 10.1016/0091-3057(95)00071-4.

DOI:10.1016/0091-3057(95)00071-4

PMID:7667381

Abstract

We studied the effect of copulation on GABA and benzodiazepine (BZD) receptors in the male mouse. After copulation, there was an 18% increase in the in vitro number of [3H]muscimol binding sites in frontal cortex. No changes were observed in central BZD binding sites labelled either in vivo by [3H]flunitrazepam or in vitro (in olfactory bulbs and in frontal cortex) by [3H]flumazenil, but further in vitro studies demonstrated that the GABA-stimulated [3H]flunitrazepam binding was reduced in both frontal cortex and olfactory bulbs. Copulation increased the number of peripheral BZD binding sites labelled by 3H-Ro 5-4864 in olfactory bulbs by 22% and in heart by 36%, but not in frontal cortex or in testes. The changes of GABA/BZD and peripheral BZD receptors in mouse suggest that the GABAergic system may be affected by copulation.

摘要

我们研究了交配对雄性小鼠体内γ-氨基丁酸（GABA）和苯二氮䓬（BZD）受体的影响。交配后，额叶皮质中[³H]蝇蕈醇结合位点的体外数量增加了18%。无论是通过[³H]氟硝西泮在体内标记的中枢BZD结合位点，还是通过[³H]氟马西尼在体外（嗅球和额叶皮质）标记的中枢BZD结合位点，均未观察到变化，但进一步的体外研究表明，GABA刺激的[³H]氟硝西泮结合在额叶皮质和嗅球中均减少。交配使嗅球中由³H-Ro 5-4864标记的外周BZD结合位点数量增加了22%，心脏中增加了36%，但在额叶皮质或睾丸中未增加。小鼠体内GABA/BZD和外周BZD受体的变化表明，GABA能系统可能受到交配的影响。