防御素

Defensins.

作者信息

Ganz T, Lehrer R I

机构信息

Department of Medicine, University of California School of Medicine, Los Angeles 90024-1736, USA.

出版信息

Pharmacol Ther. 1995 May;66(2):191-205. doi: 10.1016/0163-7258(94)00076-f.

DOI:10.1016/0163-7258(94)00076-f

PMID:7667395

Abstract

Defensins are a family of small cationic, antibiotic peptides that contain six cysteines in disulfide linkage. The peptides are abundant in phagocytes and small intestinal mucosa of humans and other mammals and in the hemolymph of insects. They contribute to host defense against microbes and may participate in tissue inflammation and endocrine regulation during infection. Bioengineered defensins are potentially useful as prophylactic and therapeutic agents in infections.

摘要

防御素是一类小的阳离子抗菌肽家族，其含有通过二硫键连接的六个半胱氨酸。这些肽在人类和其他哺乳动物的吞噬细胞及小肠黏膜以及昆虫的血淋巴中含量丰富。它们有助于宿主抵御微生物，并且在感染期间可能参与组织炎症和内分泌调节。生物工程改造的防御素在感染中作为预防和治疗剂具有潜在用途。