Gorozhanskaia E G, Patiutko I I, Sagaidak I V
Vopr Onkol. 1995;41(1):47-51.
Patients with liver tumors are known to reveal antioxidant system disorders which lead to accumulation of products of lipids peroxidation and lower resistance. Levels of malonic dialdehyde as well as the antioxidant system (superoxide dismutase, catalase, alpha-tocopherol and retinol) in liver and tumor have been followed in 28 patients in whom liver was removed to treat malignant tumors. Liver and tumor tissue were shown to contain more dialdehyde and less superoxide dismutase and catalase than in the livers of accident victims. Treatment with alpha-tocoferol (600 mg), retinol (100,000 MU) and ascorbic acid (1.5 g) for 7 days before surgery was found to significantly reduce dialdehyde level in the liver. Also, the catalase level increased. Treatment with alpha-tocoferol and retinol resulted in their selective accumulation in the liver. No changes in lipid peroxidation or accumulation of alpha-tocoferol in tumor were recorded. Purulent and septic complications were 1.6 times less frequent after preoperative antioxidant treatment than in controls. It is recommended that said antioxidant treatment should be used to correct lipid peroxidation and to improve the effectiveness of therapy of liver cancer.
已知肝脏肿瘤患者会出现抗氧化系统紊乱，这会导致脂质过氧化产物积累并降低抵抗力。对28例因治疗恶性肿瘤而切除肝脏的患者，检测了肝脏和肿瘤中丙二醛水平以及抗氧化系统（超氧化物歧化酶、过氧化氢酶、α-生育酚和视黄醇）水平。结果显示，与事故受害者的肝脏相比，肝脏和肿瘤组织中丙二醛含量更高，超氧化物歧化酶和过氧化氢酶含量更低。术前7天用α-生育酚（600毫克）、视黄醇（100,000国际单位）和抗坏血酸（1.5克）治疗，发现可显著降低肝脏中丙二醛水平，同时过氧化氢酶水平升高。用α-生育酚和视黄醇治疗导致它们在肝脏中选择性积累。未记录到肿瘤中脂质过氧化或α-生育酚积累的变化。术前抗氧化治疗后，化脓性和感染性并发症的发生率比对照组低1.6倍。建议采用上述抗氧化治疗来纠正脂质过氧化并提高肝癌治疗效果。
