Hagen A, Morack G, Grulich D
Klinik für Gynäkologie und Geburtshilfe im Klinikum Benjamin Franklin.
Zentralbl Gynakol. 1995;117(7):368-74.
In a case-control-study an epidemiological investigation of cancer of the endometrium was carried out. The study included 159 cases and 159 controls. It was shown, that woman in the sixth life decade with overweight, a smaller number of deliveries and a later menopause had a higher risk for endometrial cancer. Other risk factors are diabetes mellitus and hypertension. But it is necessary to see the relationship between the typical age for these two characteristics and the typical age for endometrial cancer. The intake of estrogens without enough gestagens during an estrogen replacement therapy was associated with an increased risk. Furthermore the patients with carcinoma of the uterine corpus had a higher incidence of malignant tumors in their families and more breast cancer in their own case history. A history of oral contraceptive use appeared to reduce the risk of endometrial cancer. In addition there is an negative association between smoking and endometrial cancer. Thus factors of high risk related to cancer of the endometrium could be defined. Preventive examinations of high risk groups could help to decrease the incidence of endometrial cancer.
在一项病例对照研究中，对子宫内膜癌进行了流行病学调查。该研究包括159例病例和159名对照。结果显示，处于生命第六个十年的女性，若超重、分娩次数较少且绝经较晚，则患子宫内膜癌的风险较高。其他风险因素包括糖尿病和高血压。但有必要审视这两个特征的典型年龄与子宫内膜癌的典型年龄之间的关系。在雌激素替代疗法期间，若摄入雌激素而没有足够的孕激素，则与风险增加相关。此外，子宫体癌患者的家族中恶性肿瘤发病率较高，且其个人病史中有更多乳腺癌病例。口服避孕药史似乎可降低子宫内膜癌的风险。此外，吸烟与子宫内膜癌之间存在负相关。因此，可以确定与子宫内膜癌相关的高危因素。对高危人群进行预防性检查有助于降低子宫内膜癌的发病率。
