Salazar-Martinez E, Lazcano-Ponce E C, Gonzalez Lira-Lira G, Escudero-De los Rios P, Salmeron-Castro J, Hernandez-Avila M
Center for Research in Population Health, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Cancer Res. 1999 Aug 1;59(15):3658-62.
A case-control study was carried out in Mexico City during 1995-1997 among women with epithelial ovarian cancer (84 cases) and endometrial cancer (85 cases). The control group consisted of 668 healthy women, matched according to age categories. In a multivariate analysis, the reproductive risk factors for ovarian and endometrial cancer are similar. The risk of ovarian cancer was inversely related to the number of full-term pregnancies; the odds ratio (OR) was 0.17 and the 95% confidence interval (CI) was 0.05-0.54 when comparing nulliparous women versus those with more than seven pregnancies. For endometrial cancer, a similar association was observed (OR, 0.11; 95% CI, 0.04-0.34). The use of oral contraceptive hormones was inversely associated with both ovarian (OR, 0.36; 95% CI, 0.15-0.83) and endometrial cancer risk (OR, 0.36; 95% CI, 0.14-0.90). In women with a history of more than 8.7 years without ovulation, the risk of ovarian cancer decreased four times (OR, 0.23; 95% CI, 0.10-0.50), and that of endometrial cancer decreased more than five times (OR, 0.17; 95% CI, 0.08-0.35). These two neoplasms are clearly typified as hormone dependent, and it is possible to establish that "ovulation" and "exfoliative" mechanisms jointly determine the level of risk for both ovarian and endometrial cancer.
1995年至1997年期间，在墨西哥城对患有上皮性卵巢癌（84例）和子宫内膜癌（85例）的女性进行了一项病例对照研究。对照组由668名健康女性组成，根据年龄类别进行匹配。在多变量分析中，卵巢癌和子宫内膜癌的生殖风险因素相似。卵巢癌风险与足月妊娠次数呈负相关；将未生育女性与生育七次以上的女性相比，比值比（OR）为0.17，95%置信区间（CI）为0.05 - 0.54。对于子宫内膜癌，观察到类似的关联（OR，0.11；95% CI，0.04 - 0.34）。口服避孕药激素的使用与卵巢癌（OR，0.36；95% CI，0.15 - 0.83）和子宫内膜癌风险（OR，0.36；95% CI，0.14 - 0.90）均呈负相关。在无排卵病史超过8.7年的女性中，卵巢癌风险降低四倍（OR，0.23；95% CI，0.10 - 0.50），子宫内膜癌风险降低超过五倍（OR，0.17；95% CI，0.08 - 0.35）。这两种肿瘤明显被归类为激素依赖性肿瘤，并且可以确定“排卵”和“剥脱”机制共同决定了卵巢癌和子宫内膜癌的风险水平。
