Beazley J M, Weekes A R
Br J Obstet Gynaecol. 1976 Jan;83(1):62-67. doi: 10.1111/j.1471-0528.1976.tb00732.x.
A prospective study of 447 labours and the resulting newborn failed to reveal any significant difference between the incidence of neonatal hyperbilirubinaemia, defined as a level of at least 205 mumol/l (12 mg/100 ml), following spontaneous labour and after labour induced or accelerated with prostaglandin E2 (PGE2). The incidence of unexplained neonatal hyperbilirubinaemia after spontaneous labour was 4-5 per cent. There was no significant association between the incidence of neonatal hyperbilirubinaemia and the total dose of PGE2 used for induction. None of the babies of the six mothers who required more than 1-5 mg of PGE2 to induce labour developed hyperbilirubinaemia. No association was demonstrated between neonatal hyperbilirubinaemia and birth weight or the duration of labour. The implications of these findings are discussed.
一项针对447例分娩及所产新生儿的前瞻性研究未能揭示自然分娩后与使用前列腺素E2（PGE2）引产或促产后，定义为胆红素水平至少达到205微摩尔/升（12毫克/100毫升）的新生儿高胆红素血症发生率之间存在任何显著差异。自然分娩后不明原因的新生儿高胆红素血症发生率为4%至5%。新生儿高胆红素血症发生率与引产所用PGE2的总剂量之间无显著关联。六位引产时需要超过1.5毫克PGE2的母亲所生的婴儿均未发生高胆红素血症。未证实新生儿高胆红素血症与出生体重或产程之间存在关联。文中讨论了这些发现的意义。
