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Evaluation of some benzyl and benzylidene monosubstituted gamma-butyrolactones and tetrahydrofurans as platelet activating factor antagonist agents.

作者信息

Coran S A, Giannellini V, Bambagiotti-Alberti M, Moriggi E, Sala R, Valle G

机构信息

Dipartimento di Scienze Farmaceutiche, Università di Firenze, Italy.

出版信息

Farmaco. 1995 Jul-Aug;50(7-8):511-8.

PMID:7669189
Abstract

Some benzyl and benzylidene monosubstituted gamma-butyrolactones and tetrahydrofurans were applied as platelet activating factor (PAF) antagonist agents. The results indicated that, whereas all benzyl derivatives are completely inactive, benzylidene substitution is the key feature for obtaining moderate activity. Molecular modeling and molecular electrostatic potential mapping are applied in conjunction with the most recent PAF-receptor model to rationalize the results.

摘要

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