Huddart R A, Wooster R, Horwich A, Cooper C S
Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, UK.
Br J Cancer. 1995 Sep;72(3):642-5. doi: 10.1038/bjc.1995.387.
DNA samples obtained from 29 testicular germ cell tumours have been screened for instability at nine different microsatellite sequences consisting of dinucleotide, trinucleotide and tetranucleotide loci. Overall, in tumours from six (21%) patients we found abnormalities in at least one of the loci examined. Mutation was most frequently found in tetranucleotide and trinucleotide repeats with only a low proportion of alterations in dinucleotide repeats. This pattern of instability is distinct from that reported in colorectal cancer and other cancers that have a high level of alterations in dinucleotide repeats.
从29例睾丸生殖细胞肿瘤中获取的DNA样本，针对由二核苷酸、三核苷酸和四核苷酸位点组成的9个不同微卫星序列的不稳定性进行了筛查。总体而言，在6例（21%）患者的肿瘤中，我们在至少一个检测位点发现了异常。突变最常出现在四核苷酸和三核苷酸重复序列中，二核苷酸重复序列中的改变比例较低。这种不稳定性模式与结直肠癌和其他在二核苷酸重复序列中有高水平改变的癌症中所报道的模式不同。
