Jankowski J, Henderson K, Viaene A, Baert J, Long L Q
Histopathology Unit, Imperial Cancer Research Fund Laboratories, Royal Postgraduate Medical School, London, United Kingdom.
Microsc Res Tech. 1995 Jun 15;31(3):184-92. doi: 10.1002/jemt.1070310303.
The molecular cell sciences have had a great impact in the analysis of the genetic and epigenetic events of esophageal and gastric tumorigenesis. In other regions of the alimentary tract such as the colon, the serial identification of the molecular events in the corresponding morphological lesions is perhaps most advanced. This is, in part, due to the relative ease of the histological characterisation of the premalignant lesions. In this regard the analysis of morphological and molecular adaptation in the alimentary tract is inextricable. This review aims, therefore, to judiciously assess the relative applications of contemporary techniques in investigative histopathology.
分子细胞科学在分析食管和胃癌发生的遗传和表观遗传事件方面产生了重大影响。在消化道的其他区域，如结肠，在相应形态学病变中对分子事件的系列鉴定可能最为先进。这在一定程度上是由于癌前病变的组织学特征相对容易确定。在这方面，消化道形态学和分子适应性的分析是密不可分的。因此，本综述旨在审慎评估当代技术在研究性组织病理学中的相关应用。
