Takada M, Yamamoto I, Yuu I, Kigami Y, Ohnaka Y, Morita R
Department of Radiology, Shiga University of Medical Science, Japan.
Endocr J. 1995 Jun;42(3):323-30. doi: 10.1507/endocrj.42.323.
Prostaglandin E2 (PGE2) has a potent bone resorbing activity in vitro, but some recent studies have shown that PGE2 stimulates bone formation in vivo. The effects of PGE2 on the bone are therefore still controversial. We attempted to reveal the effects of PGE2 on bone in vivo more directly; we injected PGE2 continuously into the bone marrow and onto the periosteum and examined the local effects of PGE2 histologically or by bone densitometry. Following PGE2 infusion into the bone marrow, new bone was formed in the bone marrow around the infused site and following PGE2 infusion onto the periosteum, extensive periosteal bone formation was observed. Bone mineral content was also increased significantly in the PGE2 infused bones. The administration of cyclic AMP did not mimic the effects of PGE2. In contrast to in vitro experiments, the in vivo effect of PGE2 is predominantly to produce bone.
前列腺素E2（PGE2）在体外具有强大的骨吸收活性，但最近的一些研究表明，PGE2在体内可刺激骨形成。因此，PGE2对骨骼的影响仍存在争议。我们试图更直接地揭示PGE2在体内对骨骼的影响；我们将PGE2持续注入骨髓和骨膜，并通过组织学或骨密度测定法检查PGE2的局部影响。将PGE2注入骨髓后，在注入部位周围的骨髓中形成了新骨，将PGE2注入骨膜后，观察到广泛的骨膜骨形成。注入PGE2的骨骼中的骨矿物质含量也显著增加。环磷酸腺苷的给药并未模拟PGE2的作用。与体外实验相反，PGE2在体内的主要作用是产生骨。
