Pohl H, DeRosa C, Holler J
Division of Toxicology, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
Chemosphere. 1995 Jul;31(1):2437-54. doi: 10.1016/0045-6535(95)00114-n.
Dioxins are among the most toxic anthropogenic chemicals in the environment. Their toxicity has been extensively studied in both humans and animals. Dioxin-contaminated soil may result in dioxins occurring in a food chain. This is especially important for the general population. It has been estimated that about 98% of exposure to dioxins is through the oral route. In the 1980s, a concentration level of 1 ppb 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in soil was specified as "a level of concern," based on cancer effects. However, recent studies indicate that end points other than cancer are also of concern. A health risk analysis scenario based on health effects of TCDD other than cancer is discussed and compared with the projected intake from 1 ppb TCDD in soil.
二噁英是环境中毒性最强的人为化学物质之一。它们的毒性已在人类和动物身上进行了广泛研究。受二噁英污染的土壤可能导致二噁英在食物链中出现。这对普通人群尤为重要。据估计，约98%的二噁英暴露是通过口服途径。在20世纪80年代，基于癌症影响，土壤中2,3,7,8-四氯二苯并对二噁英（TCDD）的浓度水平1 ppb被指定为“关注水平”。然而，最近的研究表明，除癌症外的其他终点也值得关注。本文讨论了基于TCDD除癌症外的健康影响的健康风险分析情景，并与土壤中1 ppb TCDD的预计摄入量进行了比较。
