Betoulle S, Troutaud D, Khan N, Deschaux P
Laboratoire d'immunophysiologie générale et comparée, Limoges, France.
C R Acad Sci III. 1995 Jun;318(6):677-81.
We have studied the humoral immune response (production of anti-Yersinia ruckeri antibodies), and measured the levels of plasmatic hormones (cortisol and prolactin) in rainbow trout (Oncorhynchus mykiss) subjected to hyperosmotic stress (NaCl, 22 / 1000). Under acute stressful conditions (saline stress during 7 days), high blood cortisol and prolactin (PRL) levels were correlated with a weak anti-Yersinia ruckeri antibody response, as evidenced by late and low antibody titres as compared to normal fish. Interestingly, the group of fish subjected to chronic stress (till 30 days) exhibited no significant differences in blood cortisol and prolactin levels despite low antibody titres as compared to control group. Hence, it is possible that in acute stress, cortisol and prolactin levels might exert immunosuppressive effects on antibody production, whereas in chronic stress other neuroendocrine hormones might result in curtailed humoral immunity.
我们研究了体液免疫反应（抗鲁氏耶尔森菌抗体的产生），并测量了经受高渗应激（22‰氯化钠）的虹鳟（Oncorhynchus mykiss）血浆中激素（皮质醇和催乳素）的水平。在急性应激条件下（7天的盐应激），高血皮质醇和催乳素（PRL）水平与抗鲁氏耶尔森菌抗体反应较弱相关，与正常鱼相比，抗体滴度出现得晚且低就证明了这一点。有趣的是，经受慢性应激（直至30天）的鱼群，尽管与对照组相比抗体滴度较低，但其血液皮质醇和催乳素水平没有显著差异。因此，在急性应激中，皮质醇和催乳素水平可能对抗体产生发挥免疫抑制作用，而在慢性应激中，其他神经内分泌激素可能导致体液免疫减弱。
