Saidi D, Heyman M, Kheroua O, Boudraa G, Bylsma P, Kerroucha R, Chekroun A, Maragi J A, Touhami M, Desjeux J F
Laboratoire de physiologie de la nutrition, Université d'Oran, Algérie.
C R Acad Sci III. 1995 Jun;318(6):683-9.
Weaning is a transient period of life during which maternal proteins are replaced by foreign proteins. Concomitantly, in early postnatal life, both digestive and immune systems undergo a maturation process. Allergy to cow's milk protein may develop in human infants during weaning, determining digestive, respiratory, cutaneous or systemic symptoms. We studied the intestinal response to bovine milk beta-lactoglobulin (beta-LG) in infants with cow's milk allergy, first during the active phase, and then during the symptom-free stage. During the active phase, transepithelial transport of the beta-LG across the intestinal epithelial layer stimulated the sensitized subepithelial immune cells. This stimulation induced a rise in short-circuit current suggestive of an electrogenic chloride secretion and impaired protein handling by the epithelium. These findings underline the dual role of the epithelial layer in intestinal function: on one hand, it takes an active part in allowing dietary antigens to stimulate the submucosal system, and on the other hand becomes the target for mediators involved in food allergy.
断奶是生命中的一个过渡阶段，在此期间母体蛋白质被外来蛋白质所取代。与此同时，在出生后的早期生活中，消化系统和免疫系统都会经历一个成熟过程。人类婴儿在断奶期间可能会对牛奶蛋白产生过敏反应，从而引发消化、呼吸、皮肤或全身症状。我们研究了牛奶过敏婴儿对牛乳β-乳球蛋白（β-LG）的肠道反应，首先是在过敏活动期，然后是在无症状期。在活动期，β-LG跨肠上皮层的跨上皮转运刺激了致敏的上皮下免疫细胞。这种刺激导致短路电流升高，提示存在电致氯分泌，并且上皮细胞对蛋白质的处理能力受损。这些发现强调了上皮层在肠道功能中的双重作用：一方面，它积极参与使饮食抗原刺激黏膜下系统；另一方面，它成为食物过敏相关介质的作用靶点。
