Jacques H, Lavigne C, Desrosiers T, Giroux I, Hurley C
Département de nutrition humaine et de consommation, Université Laval, Québec, Canada.
Can J Physiol Pharmacol. 1995 Apr;73(4):465-73. doi: 10.1139/y95-059.
To determine the respective and interactive effects of dietary protein source and calcium level on serum, hepatic, and fecal lipid levels, 48 male New Zealand rabbits were fed purified diets varying in the source of dietary protein, namely casein, cod protein, or soy protein, at an adequate (7 mg Ca/g diet) or a high (14 mg Ca/g diet) concentration of calcium in a 3 x 2 factorial design for 28 days. Dietary proteins interacted with dietary calcium to modulate serum and low density lipoprotein (LDL) cholesterol. When combined with the adequate-calcium diet, code protein induced higher levels of serum and LDL cholesterol than casein and soy protein, induced lower serum and LDL cholesterol than when associated with an adequate concentration of calcium. These results indicate that the hypercholesterolemic effect of cod protein is reduced in the presence of high dietary calcium. Moreover, fecal lipid content was inversely correlated with serum total (p = 0.06) and LDL (p = 0.04) cholesterol in rabbits fed cod protein diets only. An increased formation of insoluble calcium phosphate in the intestine, which may result in lower fat intestinal absorption and serum cholesterol levels, may have been responsible for the decrease in serum and LDL cholesterol in rabbits fed cod protein with high dietary calcium.
为了确定膳食蛋白质来源和钙水平对血清、肝脏及粪便脂质水平的各自及交互作用，48只雄性新西兰兔按照3×2析因设计，分别喂食蛋白质来源不同（即酪蛋白、鳕鱼蛋白或大豆蛋白）且钙浓度适宜（7毫克钙/克日粮）或高钙（14毫克钙/克日粮）的纯化日粮，为期28天。膳食蛋白质与膳食钙相互作用，调节血清和低密度脂蛋白（LDL）胆固醇水平。与适宜钙含量的日粮搭配时，鳕鱼蛋白比酪蛋白和大豆蛋白诱导产生更高水平的血清和LDL胆固醇；与高钙日粮搭配时，鳕鱼蛋白诱导产生的血清和LDL胆固醇水平低于与适宜钙浓度日粮搭配时。这些结果表明，高膳食钙可降低鳕鱼蛋白的高胆固醇血症效应。此外，仅喂食鳕鱼蛋白日粮的兔子粪便脂质含量与血清总胆固醇（p = 0.06）和LDL胆固醇（p = 0.04）呈负相关。肠道中不溶性磷酸钙形成增加，可能导致脂肪肠道吸收及血清胆固醇水平降低，这或许是喂食高膳食钙鳕鱼蛋白日粮的兔子血清和LDL胆固醇降低的原因。
