血管紧张素II（AII）和血小板衍生生长因子-BB（PDGF-BB）升高人血管平滑肌细胞（VSMCs）细胞内钙离子浓度（[Ca2+]i）的不同机制。 - Suppr

Contrasting mechanisms of intracellular calcium ([Ca2+]i) elevation by angiotensin II (AII) and platelet derived growth factor-BB (PDGF-BB) in human vascular smooth muscle cells (VSMCs).

作者信息

Clunn G F, Schachter M, Hughes A D

机构信息

Department of Clinical Pharmacology, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London.

出版信息

Biochem Soc Trans. 1995 May;23(2):170S. doi: 10.1042/bst023170s.

DOI:10.1042/bst023170s

PMID:7672196

Abstract

摘要

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Contrasting mechanisms of intracellular calcium ([Ca2+]i) elevation by angiotensin II (AII) and platelet derived growth factor-BB (PDGF-BB) in human vascular smooth muscle cells (VSMCs).血管紧张素II（AII）和血小板衍生生长因子-BB（PDGF-BB）升高人血管平滑肌细胞（VSMCs）细胞内钙离子浓度（[Ca2+]i）的不同机制。

Biochem Soc Trans. 1995 May;23(2):170S. doi: 10.1042/bst023170s.

Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases.血小板衍生生长因子-BB（PDGF-BB）对兔主动脉血管平滑肌细胞迁移和粘着斑激酶磷酸化的调节：磷脂酰肌醇3激酶和丝裂原活化蛋白激酶的作用

Cardiovasc Res. 1999 Mar;41(3):708-21. doi: 10.1016/s0008-6363(98)00232-6.

Angiotensin II-augmented migration of VSMCs towards PDGF-BB involves Pyk2 and ERK 1/2 activation.血管紧张素II增强血管平滑肌细胞向血小板源性生长因子-BB的迁移涉及Pyk2和细胞外信号调节激酶1/2的激活。

Basic Res Cardiol. 2002 Jul;97(4):334-42. doi: 10.1007/s00395-002-0357-8.

Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172).表没食子儿茶素-3-没食子酸酯选择性抑制血小板衍生生长因子-BB（PDGF-BB）诱导的血管平滑肌细胞内信号转导通路，并抑制转染sis的NIH 3T3成纤维细胞和人胶质母细胞瘤细胞（A172）的转化。

Mol Biol Cell. 1999 Apr;10(4):1093-104. doi: 10.1091/mbc.10.4.1093.

The role of platelet-derived growth factor-BB-induced increase in cytosolic free Ca2+ in activation of mitogen-activated protein kinase and DNA synthesis in vascular smooth muscle cells.血小板衍生生长因子-BB诱导的胞质游离钙离子增加在血管平滑肌细胞丝裂原活化蛋白激酶激活及DNA合成中的作用

J Hypertens. 1997 Dec;15(12 Pt 2):1671-5. doi: 10.1097/00004872-199715120-00071.

Angiotensin II and PDGF-BB stimulate beta(1)-integrin-mediated adhesion and spreading in human VSMCs.血管紧张素II和血小板衍生生长因子-BB刺激人血管平滑肌细胞中β(1)整合素介导的黏附与铺展。

Hypertension. 2000 Jan;35(1 Pt 2):255-61. doi: 10.1161/01.hyp.35.1.255.

Differential effects of lovastatin on mitogen induced calcium influx in human cultured vascular smooth muscle cells.洛伐他汀对人培养血管平滑肌细胞有丝分裂原诱导的钙内流的不同作用。

Br J Pharmacol. 1997 Aug;121(8):1789-95. doi: 10.1038/sj.bjp.0701299.

CV-11974, the active metabolite of TCV-116 (Candesarten), inhibits the synergistic or additive effect of different growth factors on angiotensin II-induced proliferation of vascular smooth muscle cells.CV-11974是替米沙坦（TCV-116）的活性代谢产物，它可抑制不同生长因子对血管紧张素II诱导的血管平滑肌细胞增殖的协同或相加作用。

Biochem Pharmacol. 1996 Jul 12;52(1):123-6. doi: 10.1016/0006-2952(96)00171-2.

Growth factors mediate intracellular signaling in vascular smooth muscle cells through protein kinase C-linked pathways.生长因子通过蛋白激酶C相关途径介导血管平滑肌细胞内的信号传导。

Hypertension. 1997 Dec;30(6):1440-7. doi: 10.1161/01.hyp.30.6.1440.

Platelet-derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells.血小板衍生生长因子和血管紧张素II通过不同机制使血管平滑肌细胞胞质游离钙增加。

J Cell Physiol. 1989 Apr;139(1):100-8. doi: 10.1002/jcp.1041390115.

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Contrasting mechanisms of intracellular calcium ([Ca2+]i) elevation by angiotensin II (AII) and platelet derived growth factor-BB (PDGF-BB) in human vascular smooth muscle cells (VSMCs).

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