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The role of phosphatidylinositol 3-kinase activity in insulin-stimulated mitogenesis in 3T3-L1 adipocytes.

作者信息

Haigh R J, Shepherd P R, Navé B T, Siddle K

机构信息

Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, U.K.

出版信息

Biochem Soc Trans. 1995 May;23(2):179S. doi: 10.1042/bst023179s.

DOI:10.1042/bst023179s
PMID:7672203
Abstract
摘要

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The role of phosphatidylinositol 3-kinase activity in insulin-stimulated mitogenesis in 3T3-L1 adipocytes.磷脂酰肌醇3激酶活性在3T3-L1脂肪细胞胰岛素刺激的有丝分裂中的作用。
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Phosphatidylinositol 3'-kinase, but not p70 ribosomal S6 kinase, is involved in membrane protein recycling: wortmannin inhibits glucose transport and downregulates cell-surface transferrin receptor numbers independently of any effect on fluid-phase endocytosis in fibroblasts.磷脂酰肌醇3'-激酶而非p70核糖体S6激酶参与膜蛋白循环：渥曼青霉素抑制葡萄糖转运并下调细胞表面转铁蛋白受体数量，且与对成纤维细胞液相内吞作用的任何影响无关。
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