Shenoy M A, George K C, Singh B B, Gopal-Ayengar A R
Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Dec;28(6):519-26. doi: 10.1080/09553007514551381.
Chlorpromazine sensitized E. COLI B/r, thymocytes and Yoshida ascites-tumour cells to 60Co gamma-rays, preferentially, under hypoxic conditions, Residual sensitization was observed in E. coli B/r. The radiosensitization by chlorpromazine was found to be due to the reaction of radiolytically-induced hydroxyl radicals with the sensitizer. When both procaine HCI and chlorpromazine were present during anoxic irradiation of E. coli B/r, there was no additive effect. But the addition of procaine HCL after irradiation to cell sensitized by chlorpromazine had an effect that was significantly greater than that produced even by oxygen. A similar effect was observed when lignocaine or tetracaine was used in place of procaine. The possible mechanisms involved in radiosensitization by chlorpromazine and in the post-irradiation effect of local anaesthetics in cells sensitized to 60Co gamma-rays by chlorpromazine are discussed.
氯丙嗪优先使大肠杆菌B/r、胸腺细胞和吉田腹水瘤细胞在缺氧条件下对60Coγ射线敏感。在大肠杆菌B/r中观察到残余敏感性。发现氯丙嗪的放射增敏作用是由于辐射诱导的羟基自由基与敏化剂的反应。当在大肠杆菌B/r的缺氧照射期间同时存在盐酸普鲁卡因和氯丙嗪时，没有相加效应。但是在照射后向经氯丙嗪敏化的细胞中添加盐酸普鲁卡因产生的效应甚至比氧气产生的效应还要显著得多。当用利多卡因或丁卡因代替普鲁卡因时，观察到类似的效应。讨论了氯丙嗪放射增敏以及局部麻醉药在经氯丙嗪敏化的细胞中对60Coγ射线照射后的效应所涉及的可能机制。
