Kiene P, Fölster-Holst R, Mielke V
Universitäts-Hautklinik, Kiel.
Hautarzt. 1995 Jul;46(7):498-501. doi: 10.1007/s001050050290.
We report on a 34-year-old male patient who developed generalized parakeratosis variegata lesions 4 years after suffering from pityriasis lichenoides et varioliformis acuta. For further investigation of a possible interrelationship between these two diseases of the parapsoriasis group and their relationship to the T-cell type of cutaneous non-Hodgkin-lymphoma, histological, immunohistological and molecular-biological techniques were applied. We were able to demonstrate typical morphological features common to both diseases, and a polyclonal T-cell infiltrate in both. It is concluded that pityriasis lichenoides et varioliformis acuta and parakeratosis variegata are separate entities without monoclonal rearrangement or signs of malignancy.
我们报告了一名34岁男性患者,该患者在急性痘疮样苔藓样糠疹发作4年后出现了泛发性杂色角化不全性损害。为了进一步研究副银屑病组这两种疾病之间可能的相互关系以及它们与皮肤非霍奇金淋巴瘤T细胞型的关系,我们应用了组织学、免疫组织化学和分子生物学技术。我们能够证明这两种疾病共有的典型形态学特征,以及两者中均存在多克隆T细胞浸润。结论是,急性痘疮样苔藓样糠疹和杂色角化不全性损害是独立的实体,不存在单克隆重排或恶性迹象。