Karger C P, Hartmann G H, Hoffmann U, Lorenz W J
German Cancer Research Center, Department of Biophysics and Medical Radiation Physics, Heidelberg.
Int J Radiat Oncol Biol Phys. 1995 Sep 30;33(2):485-92. doi: 10.1016/0360-3016(95)00066-8.
A stereotactic fixation and localization device developed for small animal stereotactic radiosurgery is described.
Irradiated volumes of spherical shape down to 1.7 mm in diameter at the 80% isodose level are attainable. The fixation device can also be used for magnetic resonance imaging (MRI) and allows target localization during magnetic resonance (MR) image content measurement. The capabilities of the entire system were investigated using a phantom that permitted measurement and localization of the three-dimensional dose distribution. Localization of target isocenter coordinates in MR images was also checked with the phantom.
An overall spatial error of about 1 mm for subsequent stereotactic irradiation was obtained.
The accuracy of the fixation and localization techniques is adequate to investigate radiation-induced changes in the rat brain.
描述一种为小动物立体定向放射外科手术开发的立体定向固定和定位装置。
在80%等剂量水平下可实现直径低至1.7毫米的球形照射体积。该固定装置还可用于磁共振成像（MRI），并允许在磁共振（MR）图像内容测量期间进行靶点定位。使用一个允许测量和定位三维剂量分布的体模研究了整个系统的性能。还使用该体模检查了MR图像中靶点等中心坐标的定位。
后续立体定向照射的总体空间误差约为1毫米。
固定和定位技术的准确性足以研究大鼠脑部辐射诱导的变化。
