O'Malley S S
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
J Clin Psychiatry. 1995;56 Suppl 7:30-8.
Numerous studies suggest that an integration of pharmacologic, psychological, and social therapies may lead to improved treatment outcomes for alcohol-dependent patients. This article discusses studies that show the benefits of treating opiate addiction and alcohol dependence with a combination of naltrexone and psychosocial therapies. It also reviews clinical strategies that may maximize the effectiveness of combining pharmacologic and psychosocial therapies for alcoholism. By matching patients with treatments and combining pharmacologic and psychosocial therapies, health care professionals may help alcohol-dependent patients avoid relapse and achieve sobriety. Determining the optimal amount of time an alcohol-dependent patient should be treated with naltrexone requires further study. The value of initiating naltrexone therapy during inpatient treatment should also be explored.
众多研究表明，药物治疗、心理治疗和社会治疗相结合可能会改善酒精依赖患者的治疗效果。本文讨论了一些研究，这些研究显示了纳曲酮与心理社会治疗相结合治疗阿片类成瘾和酒精依赖的益处。它还回顾了一些临床策略，这些策略可能会使药物治疗和心理社会治疗相结合治疗酒精中毒的效果最大化。通过为患者匹配治疗方法并将药物治疗和心理社会治疗相结合，医疗保健专业人员可以帮助酒精依赖患者避免复发并实现戒酒。确定酒精依赖患者使用纳曲酮治疗的最佳时长需要进一步研究。还应探索在住院治疗期间开始纳曲酮治疗的价值。
