Teh B T, Cardinal J, Shepherd J, Hayward N K, Weber G, Cameron D, Larsson C
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
J Intern Med. 1995 Sep;238(3):249-53. doi: 10.1111/j.1365-2796.1995.tb00931.x.
Oncogenesis of tumours related to multiple endocrine neoplasia type 1 (MEN1) is associated with somatic deletions involving the MEN1 locus at chromosomal region 11q13, suggesting inactivation of a tumour-suppressor gene in this region. Here we describe the localization of the MEN1 gene to a 900-kb region, based on linkage analysis in affected families and deletion mapping of MEN1-associated tumours. In addition, a set of microsatellite markers mapped to the 11q11-13 region were used for linkage analysis in a large Tasmanian MEN1 pedigree, demonstrating the usefulness of these markers for presymptomatic testing in affected families.
与1型多发性内分泌肿瘤（MEN1）相关的肿瘤发生与涉及染色体区域11q13上MEN1位点的体细胞缺失有关，这表明该区域的一个肿瘤抑制基因失活。在此，我们基于对患病家族的连锁分析以及MEN1相关肿瘤的缺失定位，将MEN1基因定位到一个900 kb的区域。此外，一组定位于11q11 - 13区域的微卫星标记被用于一个大型塔斯马尼亚MEN1家系的连锁分析，证明了这些标记在患病家族症状前检测中的有用性。
