Wedeen C J
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA.
J Neurobiol. 1995 Jul;27(3):277-93. doi: 10.1002/neu.480270303.
Regionalization and segmentation of the leech body plan have been examined by numerous approaches over the years. A wealth of knowledge has accumulated regarding the normally invariant cell lineages of the leech and the degree of developmental plasticity that is possible in each cell line in early development and in neurogenesis. Homologues of genes that control regionalization and segmentation in Drosophila have been cloned from the leech and the expression patterns reveal conserved features with those in Drosophila and other organisms. Possible developmental functions of the en-class proteins in spatial and temporal modes of segment formation are discussed in light of leech and Drosophila development. Annelida and Arthropoda cell lineages of engrailed-class gene expression are compared in leech blast cell clones and crustacean parasegments. In addition, future directions for molecular analysis of segmentation of the leech are summarized.
多年来，人们通过多种方法研究了水蛭身体结构的区域化和分割。关于水蛭正常不变的细胞谱系以及早期发育和神经发生中每个细胞谱系可能的发育可塑性，已经积累了丰富的知识。从水蛭中克隆出了控制果蝇区域化和分割的同源基因，其表达模式显示出与果蝇和其他生物体中的保守特征。根据水蛭和果蝇的发育情况，讨论了en类蛋白在节段形成的空间和时间模式中可能的发育功能。在水蛭胚细胞克隆和甲壳类副节中比较了环节动物和节肢动物engrailed类基因表达的细胞谱系。此外，还总结了水蛭分割分子分析的未来方向。
