Chen R, Macdonald D R, Ramsay D A
Department of Clinical Neurological Sciences, Victoria Hospital, University of Western Ontario, Canada.
J Neurosurg. 1995 Oct;83(4):724-8. doi: 10.3171/jns.1995.83.4.0724.
The authors describe a case of a diffuse primary leptomeningeal oligodendroglioma in a 17-year-old girl who presented with raised intracranial pressure and hydrocephalus. She underwent imaging studies and a left frontotemporal craniotomy that revealed a cystic oligodendroglioma in the suprasellar cistern and spread of neoplastic cells to the spinal leptomeninges. The tumor showed little response to maximum radiotherapy and chemotherapy, and the patient died from complications of high-dose chemotherapy 2 years after diagnosis. Postmortem examination of the brain and spinal cord revealed diffuse meningeal infiltration by neoplastic cells and no evidence of an intraparenchymal origin. Glial heterotopias were noted at several sites along the brain base, adding circumstantial support to the theory that leptomeningeal gliomas are derived from ectopic glial tissue in the subarachnoid space.
作者描述了一例17岁女孩的弥漫性原发性软脑膜少突胶质细胞瘤，该女孩表现为颅内压升高和脑积水。她接受了影像学检查及左额颞开颅手术，结果显示鞍上池有一个囊性少突胶质细胞瘤，且肿瘤细胞扩散至脊髓软脑膜。该肿瘤对最大剂量的放疗和化疗反应甚微，患者在诊断后2年死于高剂量化疗的并发症。对脑和脊髓进行的尸检显示，肿瘤细胞弥漫性浸润脑膜，无实质内起源的证据。在脑底部的几个部位发现了胶质异位，这为软脑膜胶质瘤起源于蛛网膜下腔异位胶质组织的理论提供了间接支持。
